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The San Francisco 49ers (5-4) and the Arizona Cardinals (4-6) meet at Estadio Azteca in Mexico City, Mexico on Monday, November 21, 2022.
The 49ers are significant favorites (-8) in their game against the Cardinals, with the over/under at 43.5 points. (In terms of the moneyline, the 49ers are -354 and the Cardinals are +278.)
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Game Info, Betting Lines for San Francisco 49ers vs. Arizona Cardinals
- Game Day: Monday, November 21, 2022
- Game Time: 8:15 PM ET
- TV Channel: ESPN
- Location: Mexico City, Mexico
- Stadium: Estadio Azteca
| Favorite | Spread | Favorite Spread Odds | Underdog Spread Odds | Total | Over Total Odds | Under Total Odds | Favorite Moneyline | Underdog Moneyline |
|---|---|---|---|---|---|---|---|---|
| 49ers | -8 | -110 | -110 | 43.5 | -110 | -111 | -354 | +278 |
Betting Insights for 49ers
- The 49ers have posted a 4-5-0 record against the spread this season.
- In games they have played as at least 8-point favorites this season, the 49ers are 1-0 against the spread.
- 49ers games have gone over the point total on three of nine occasions (33.3%).
Stats & Insights for 49ers
- Defensively, the 49ers have been a top-five unit, ranking best by allowing only 280.6 yards per game. They rank ninth on offense (360 yards per game).
- The 49ers have the 18th-ranked offense this year (22 points per game), and they’ve been more effective on the other side of the ball, ranking fifth-best with only 18.1 points allowed per game.
- The 49ers are putting up 236.3 passing yards per game offensively this season (11th in NFL), and they are surrendering 197.9 passing yards per game (eighth) on the other side of the ball.
- The 49ers have the 14th-ranked offense this season in terms of rushing yards (123.7 per game), and they’ve been more effective defensively, ranking best with only 82.7 rushing yards allowed per game.
- Offensively, the 49ers have been a top-five unit in terms of third-down efficiency, ranking fifth-best in the NFL by putting up a 45.6% third-down percentage. They rank 18th on defense (41% third-down conversion rate allowed).
- The 49ers have been finding success on both sides of the ball in terms of yards per play, ranking fifth-best in yards per play on offense (6.1) and best in yards per play allowed on defense (5).
- The 49ers rank 24th in the NFL with a -3 turnover margin after forcing 10 turnovers (19th in the NFL) and committing 13 (19th in the NFL).
49ers’ Best Players
- Jimmy Garoppolo: 1,931 PASS YDS / 241.4 YPG / 66.8% / 11 TD / 4 INT
- Christian McCaffrey: 125 CAR / 563 YDS / 62.6 YPG / 4 TD / 47 REC / 395 YDS / 43.9 YPG / 2 TD
- Deebo Samuel: 28 CAR / 165 YDS / 20.6 YPG / 1 TD / 34 REC / 411 YDS / 51.4 YPG / 2 TD
- Brandon Aiyuk: 44 REC / 567 YDS / 63 YPG / 4 TD
- Nick Bosa: 27 TKL / 11 TFL / 9.5 SACK
- Fred Warner: 69 TKL / 1 TFL / 1 SACK / 6 PD
- Talanoa Hufanga: 50 TKL / 5 TFL / 1 SACK / 4 INT / 7 PD
Betting Insights for Cardinals
- The Cardinals have a 5-5-0 record against the spread this year.
- Out of the Cardinals’ 10 games with a set total, six have hit the over (60%).
Stats & Insights for Cardinals
- The Cardinals are accumulating 333.7 total yards per game on offense this season (19th-ranked). Meanwhile, they are giving up 357.6 total yards per contest (22nd-ranked).
- The Cardinals have been struggling defensively, ranking third-worst with 25.8 points allowed per game. They have been more productive on offense, regstering 23 points per contest (13th-ranked).
- In terms of passing, the Cardinals rank 18th in the NFL (220.6 passing yards per game) and 23rd on defense (247.1 passing yards allowed per game).
- From an offensive angle, the Cardinals are compiling 113.1 rushing yards per contest (19th-ranked). They rank ninth in the NFL defensively (110.5 rushing yards given up per game).
- In terms of third-down efficiency, the Cardinals rank 26th in the NFL (34.8% third-down conversion percentage) and 26th on defense (44% third-down rate allowed).
- The Cardinals’ offense has been sputtering in terms of yards per play, ranking fifth-worst in the NFL at 5.2. They have been more productive on the defensive side of the ball, giving up 5.9 yards per play (20th-ranked).
- The Cardinals have thrived in terms of turnovers, as the team’s turnover margin of +5 ranks fifth-best in the NFL, with 14 forced turnovers (eighth in league) and nine turnovers committed (fourth in league).
Best Players for Cardinals
- Kyler Murray: 2,168 PASS YDS / 240.9 YPG / 66.7% / 12 TD / 6 INT / 59 CAR / 359 RUSH YDS / 2 TD
- James Conner: 82 CAR / 314 YDS / 44.9 YPG / 3 TD / 22 REC / 139 YDS / 19.9 YPG / 0 TD
- Rondale Moore: 41 REC / 414 YDS / 59.1 YPG / 1 TD
- Zach Ertz: 47 REC / 406 YDS / 40.6 YPG / 4 TD
- DeAndre Hopkins: 36 REC / 396 YDS / 99 YPG / 2 TD
- J.J. Watt: 18 TKL / 7 TFL / 5.5 SACK / 3 PD
- Budda Baker: 75 TKL / 1 TFL / 1 INT / 3 PD
